Dale E Bredesen Selected Research

monosulfiram (sulfiram)

1/2012

Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain.

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Dale E Bredesen Research Topics

Disease

45	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 07/2002
7	Cognitive Dysfunction 01/2022 - 06/2013
5	Inflammation (Inflammations) 01/2022 - 08/2015
5	Neoplasms (Cancer) 09/2009 - 02/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2018 - 12/2004
3	Insulin Resistance 01/2022 - 08/2015
2	Vascular Diseases (Vascular Disease) 01/2022 - 01/2011
2	Dementia (Dementias) 01/2022 - 01/2021
2	Cardiovascular Diseases (Cardiovascular Disease) 06/2018 - 01/2016
2	Atrophy 01/2010 - 05/2006
2	Colorectal Neoplasms (Colorectal Cancer) 09/2004 - 06/2003
2	Amyloid Plaque 08/2004 - 11/2003
1	Persistent Infection 01/2022
1	Dysbiosis 01/2022
1	Hypoxia (Hypoxemia) 01/2022
1	Disease Progression 01/2021
1	Mixed Dementias 01/2021
1	Tauopathies 12/2018
1	Glioblastoma (Glioblastoma Multiforme) 01/2017
1	Lewy Body Disease (Lewy Body Dementia) 01/2016
1	Dyscalculia 08/2015
1	Aphasia (Dysphasia) 08/2015
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2015
1	Neuroblastoma 01/2012
1	Myocardial Infarction 01/2011
1	Rhabdomyolysis 01/2011
1	Stroke (Strokes) 01/2011
1	Memory Disorders (Memory Loss) 01/2010
1	Melanoma (Melanoma, Malignant) 07/2008
1	Parkinson Disease (Parkinson's Disease) 01/2008
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 10/2007
1	Gliosis 05/2006
1	Adenoma (Adenomas) 09/2004
1	Carcinogenesis 09/2004
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 09/2004
1	Prostatic Neoplasms (Prostate Cancer) 02/2002

Drug/Important Bio-Agent (IBA)

24	Proteins (Proteins, Gene)FDA Link 01/2017 - 07/2002
18	Amyloid (Amyloid Fibrils)IBA 01/2016 - 10/2003
13	Amyloid beta-PeptidesIBA 12/2012 - 07/2002
12	Peptides (Polypeptides)IBA 01/2016 - 02/2002
5	Pharmaceutical PreparationsIBA 01/2021 - 06/2012
5	CaspasesIBA 01/2017 - 12/2003
4	ApolipoproteinsIBA 06/2018 - 11/2013
4	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 06/2015 - 11/2003
3	Apolipoproteins E (ApoE)IBA 01/2017 - 11/2013
3	Amino Acids FDA Link 08/2008 - 07/2002
2	LipidsIBA 06/2018 - 01/2016
2	Apolipoprotein E4IBA 06/2018 - 01/2016
2	Carrier Proteins (Binding Protein)IBA 06/2018 - 01/2016
2	Netrin-1IBA 01/2016 - 09/2004
2	Pyridinolcarbamate (P23)IBA 01/2013 - 02/2012
2	Methionine (L-Methionine)FDA Link 12/2012 - 01/2010
2	Phosphotransferases (Kinase)IBA 01/2004 - 10/2003
1	Hormones (Hormone)IBA 01/2022
1	Sirtuin 1IBA 12/2018
1	Apolipoprotein E3IBA 01/2017
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2017
1	MycotoxinsIBA 02/2016
1	DNA (Deoxyribonucleic Acid)IBA 01/2016
1	Nerve Growth Factors (Neurotrophins)IBA 01/2016
1	SirtuinsIBA 01/2016
1	NetrinsIBA 01/2016
1	ZincIBA 08/2015
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2015
1	AntioxidantsIBA 07/2015
1	resolvin D1IBA 07/2015
1	CarbohydratesIBA 01/2015
1	EnzymesIBA 01/2015
1	Dextroamphetamine (Dexedrine)FDA LinkGeneric 01/2015
1	Tropisetron (Navoban)IBA 03/2014
1	ProdrugsIBA 01/2013
1	FlavonoidsIBA 01/2013
1	Biological ProductsIBA 06/2012
1	AntibodiesIBA 02/2012
1	Disulfiram (Antabuse)FDA Link 01/2012
1	monosulfiram (sulfiram)IBA 01/2012
1	CholesterolIBA 01/2011
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2011
1	cerivastatin (Kazak)FDA Link 01/2011
1	Aspartic Acid (Aspartate)FDA Link 01/2010
1	3-nitrotyrosineIBA 01/2010
1	ResveratrolIBA 09/2009
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2009
1	MetalsIBA 06/2009
1	ElementsIBA 06/2009
1	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 03/2009
1	LigandsIBA 03/2009
1	Nerve Growth Factor (NGF)IBA 03/2009
1	CurcuminIBA 07/2008
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 07/2008
1	p21-Activated KinasesIBA 02/2008
1	Mutant Proteins (Protein, Mutant)IBA 01/2008
1	Cholinergic Agents (Cholinergics)IBA 12/2007
1	polyglutamineIBA 10/2007
1	Death Domain ReceptorsIBA 06/2003
1	Type I Tumor Necrosis Factor ReceptorsIBA 06/2003

Therapy/Procedure

11	Therapeutics 01/2022 - 12/2004
2	Precision Medicine 01/2022 - 01/2021
1	Drug Therapy (Chemotherapy) 07/2008